Immune responses to fusion proteins

Details Immune responses to fusion proteins Immune responses to fusion proteins

2005-08-30

2005-08-30

Wehbé, Anne Marie S. (Department: 1632)

Chemistry: molecular biology and microbiology

Vector, per se

C435S455000, C435S004000, C435S325000, C514S04400A

Reexamination Certificate

active

06936464

ABSTRACT:
The invention relates to a nucleic acid construct for delivery into living cells in vivo for inducing an immune response in a patient to an idiotypic determinant present on a malignant B cell in the patient; the construct directing the expression of a fusion protein, said fusion protein comprising the idiotypic determinant and at least one T helper cell epitope from tetanus toxin. The invention further relates to a method of making the nucleic acid construct, a method of treating a patient, and to a composition comprising the nucleic acid construct.

REFERENCES:
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5910488 (1999-06-01), Nabel et al.
patent: 6214804 (2001-04-01), Felgner et al.
patent: 6413942 (2002-07-01), Felgner et al.
patent: 90 11092 (1990-10-01), None
patent: WO 90/11092 (1990-10-01), None
patent: 92 01047 (1992-01-01), None
Ross et al. Human Gene Therapy, vol. 7, 1781-1790, Sep. 1996.
Orkin et al. “Report and Recommendations of the panel to assess the NIH investment in research on gene therapy”, Dec. 1995.
Marshall et al. Science, vol. 269, 1050-1055, Aug. 1995.
Verma et al. Science, vol. 389, 239-242, Sep. 1997.
Marshall et al. Science, vol. 269, 1050-1055, Aug. 1995.
Verma et al. Science, vol. 389, 239-242, Sep. 1997.
Hawkins et al. (1993) Br. J. Cancer, vol. 67 (Suppl. XX):13.
Yu et al. (1994) Int. J. Cancer, vol. 56, 244-248.
Ross et al. Human Gene Therapy, vol. 7, 1781-1790, Sep. 1996.
Orkin et al. “Report and Recommendations of the panel to assess the NIH investment in research on gene therapy”, Dec. 1995.
Hawkins et al (1992) Cell selection strategies for making antibodies from variable gene libraries: trapping the memory pool, European Journal of Immunology, vol 22, pp. 867-870.
Campbell et al (1987) “Idiotype vaccination against murine B cell lymphoma”, Journal of Immunology, vol 139, pp. 2825-2833.
Embleton et al (1992) “In-cell PCR from mRNA: amplifying and linking the rearranged immunoglobulin heavy and light chain V-genes within single cells”, Nucleic Acids Research, vol 20, pp. 3831-3837.
Marks et al (1992) “By-passing immunization: Building high affinity human antibodies by chain shuffling”, Bio/Technology, vol 10, pp. 779-783.
Davis et al (1991) “Single chain antibody encoding genes: one-step construction and expression in eucaryotic cells”, Bio/Technology, vol 9, pp. 165-169.
George et al (1989) “Prospects for the treatment of B cell tumors using idiotypic vaccination”, International Reviews of Immunology, vol 4, pp. 271-310
Tang et al (1992) “Genetic immunication is a simply method for elicting an immune response”, Nature, vol 356, pp. 152-1546.
Hinuma et al (1991) “A novel strategy for converting recombinant viral protein into high immunogenic antigen”, FEBS Letters, vol 288, pp. 138-142.
Hawkins et al (1992) “Selection of phase antibodies by binding affinity”, Journal of Molecular Biology, vol 226, pp. 889-896.
Tao et al (1992) “Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphome”, Nature, vol 362, pp. 755-758.
Coughlan (1995) “Gene dream fades away”, New Scientist, pp. 14-15.
Brown (1995) “Gene therapy oversold by researchers, journalists”, The Washington Post, pp. A1 and A22.
Marshall (1995) “Gene therapy's growing pains”, Science, vol 269, pp. 1050-1055.
Rosenberg (1995) “Immunotherapy and gene therapy of cancer”, Cancer Research, vol 51, pp. 5074s-5079s.
Stevenson et al (1995) “Idiotypic DNA vaccines against B-cell lymphoma”Immunological Reviews, vol 145, pp. 211-228.
Syrengelas et al (1996) “DNA immunization induces protective immunity against B-cell lymphoma” Nature Medicine, vol 2, pp. 1038-1041.

Affiliated with

Also associated with

Rating

Immune responses to fusion proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immune responses to fusion proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immune responses to fusion proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3456916