Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-06
2000-06-13
Johnson, Nancy A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530806, 530828, C07K 1447, C07K 14705
Patent
active
060751223
ABSTRACT:
Methods for the detection, monitoring and treatment of malignancies in which the HER-2
eu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2
eu protein, or detection of immunocomplexes formed between the HER-2
eu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2
eu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.
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Cheever Martin A.
Disis Mary L.
Johnson Nancy A.
University of Washington
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