Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Reexamination Certificate
2007-07-24
2007-07-24
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
C530S326000, C530S300000, C530S350000, C530S403000, C530S402000, C424S184100, C424S185100, C424S277100, C514S002600, C514S014800, C514S015800, C930S010000
Reexamination Certificate
active
10647005
ABSTRACT:
Methods for the detection, monitoring and treatment of malignancies in which the HER-2
eu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2
eu protein, or detection of immunocomplexes formed between the HER-2
eu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2
eu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.
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Cheever Martin A
Disis Mary L
Helms Larry R.
Holleran Anne L.
Seed IP Law Group PLLC
University of Washington
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