Immune complex assay

Details Immune complex assay Immune complex assay

1985-01-11

1987-12-08

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 7, 435 68, 435803, 436506, 436507, 436518, 436161, 436821, 436828, G01N 3353, G01N 33564, G01N 33543, C12Q 100

Patent

active

047118393

ABSTRACT:
A novel method for detecting tumor associated antigen in patient's serum or plasma samples is provided. Tumor associated antigen in the form of immune complexes is detected by first applying the patient's serum sample to an immunoadsorbent column to enrich the amount of immune complexes relative to other serum components. The amount of tumor associated antigen is then detected in the enriched sample in a solid-phase assay employing a solid-phase receptor for the immune complexes and a labelling system specific for the tumor associated antigen.

REFERENCES:
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Jones et al., Journal of Immunological Methods, vol. 44, pp. 249-270, 1981.
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Gupta et al., (1983) Clin. exp. Immunol. 53:589-599.
Theofilopoulous et al., (1978) J. Clin. Invest. 59:1570-1581.

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