Immune cell proliferation inhibitors

Details Immune cell proliferation inhibitors Immune cell proliferation inhibitors

1989-01-11

1991-08-13

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, A61K 3702, A61K 39395

Patent

active

050395211

ABSTRACT:
A method for the treatment of immune system disorders in humans by administration of pp14; derivatives, fragments, or subunits of pp14; or monoclonal antibodies thereto. The method may be used to treat allergic disorders, autoimmune disorders, inflammatory disorders, lymphoproliferation disorders, and neoplastic disorders. Monoclonal antibodies to pp14, and the hybridoma cell lines which produce them. A method for the detection and quantitation of pp14 using monoclonal antibodies thereto, as well as a method for the purification of pp14 using an affinity or immuno-precipitation reaction.

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Pockley et al., "Placental Protein 14 (PP14) Inhibits the Synthesis of Interleukin-2 and the Release of Soluble Interleukin-2 Receptors from Phytohaemagglutinin-Stimulated Lymphocytes", Clin. Exp. Immunol. (1989) 77, pp. 252-256.
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