Immune cell proliferation inhibitors

Details Immune cell proliferation inhibitors Immune cell proliferation inhibitors

1991-06-28

1993-10-26

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, A61K 39395, A61K 3700

Patent

active

052564118

ABSTRACT:
A method for treating an immune system disorder in a human by administering to the human a therapeutically effective amount of an active substance selected from the group consisting of PP14, derivatives of PP14, muteins of PP14, fragments of PP14, and subunits of PP14, to alleviate the immune system disorder.

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patent: 4766069 (1988-08-01), Auron et al.
Pockley, A. G., "An Investigation Into the Immunomodulatory Activities of Human Placental Protein 14 (PP14)," Chem. Abst., vol. 111 (1989).
Pockley et al., "Placental Protein 14 (PP14) Inhibits the Synthesis of Interleukin-2 and the Release of Soluble Interleukin-2 Receptors from the Phytohaemagglutinin-stimulated Lymphocytes," Clin. Exp. Immunol. (1989) 77, pp. 252-256.
Bolton et al., "The Radioimmunassay of Human Placental Protein 14 (PP14)", Clinica Chimica Acta, 135 (1983), pp. 283-291.
A. G. Pockley, et al., "Suppression of In Vitro Lymphocyte Reactivity to Phytohemagglutinin by Placental Protein 14," Journal of Reproductive Immunology, vol. 13, 1988, pp. 31-39.
A. E. Bolton et al., "Identification of Placental Protein 14 as an Immunosuppressive Factor in Human Reproduction," The Lancet, Mar. 14, 1987, pp. 593-595.
M. Julkunen et al., "Complete Amino Acid Sequence of Human Placental Protein 14: A Progesterone-Regulated Uterine Protein Homologous to Beta-Lactoglobulins," Proc. Natl. Acad. Sci. U.S.A., vol. 85, Dec. 1988, pp. 8845-8849.
Pockley et al., "The Effect of Human Placental Protein 14 (PP14) on the Production of Interleukin-1 from Mitogenically Stimulated Mononuclear Cell Cultures," Immunology (1990) 69, pp. 277-281.

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