Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Rodent cell – per se
Reexamination Certificate
2001-02-14
2008-01-08
Woitach, Joseph (Department: 1633)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Rodent cell, per se
C435S455000, C435S375000, C435S378000
Reexamination Certificate
active
07316926
ABSTRACT:
To provide an immortalized capillary pericyte line which maintains the original function/property of the cell line-deriving tissue, its establishment method, and the screening method for useful substance using the immortalized capillary pericyte line. Cerebral tissue of a transgenic rat carrying the large T antigen gene of SV40 thermo-sensitive mutant line tsA58 is homogenized and the resultant brain capillaries are treated with protease, thus obtained brain capillary cells are subcultured to establish an immortalized cell that expresses SV40 thermo-sensitive large T antigen, PDGF receptor β, and Angiopoietin-1. In addition, the immortalized vascular pericyte line has ability to deposit calcium on matrix by dense culture.
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Hattori Kenji
Iizasa Hisashi
Nakashima Emi
Obinata Masuo
Terasaki Tetsuya
Japan Science and Technology Agency
Morgan & Finnegan L.L.P.
Popa Ileana
Woitach Joseph
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