Immortalized T-lymphocyte cell line for testing HTLV-III inactiv

Details Immortalized T-lymphocyte cell line for testing HTLV-III inactiv Immortalized T-lymphocyte cell line for testing HTLV-III inactiv

1985-09-30

1987-11-03

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 4, 435 5, 435 29, 435235, 435236, 435240, 435948, 514 42, 536 22, C12N 500, C12N 704, C12Q 118

Patent

active

047043571

ABSTRACT:
This invention is an immortalized T-cell clone, designated ATH8, which is highly sensitive to the cytopathic effect of HTLV-III. The ATH8 T-cell clone is used in mass screening systems to rapidly and easily determine the in vitro capacity of new drugs or other agents to inactivate or inhibit HTLV-III or related cytopathic retroviruses.

REFERENCES:
patent: 4329424 (1982-05-01), Machlowitz
patent: 4520113 (1985-05-01), Gallo
patent: 4604351 (1986-08-01), Amaral
patent: 4620930 (1986-11-01), McDowell
patent: 4622297 (1986-11-01), Kappner
Popovic, M. et al., Science 224:497-500 (5-1984).
Mitsuya, H. et al., Science 225:1484-1486 (9-1984).
Mitsuya, H. et al., Science 226:172-174 (10-1984).
Science, vol. 229, pp. 563-570 (Aug. 9, 1985).
Proc. Natl. Acad. Sci., Microbiology: Folks et al., pp. 4539-4543, U.S.A. (1985).

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