Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1998-10-30
2000-07-18
Yucel, Remy
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435325, 435352, 435353, 435354, 435363, 435366, C12N 508
Patent
active
060906243
ABSTRACT:
Immortalized cell lines of retinal origin (retinal endothelial and retinal pigmentary epithelial origin) which are capable of being implanted in the retina and of conveying a substance of therapeutic interest into the eye and the central nervous system. Such lines can also serve as a model for studying the blood/central nervous system interfaces.
These lines are derived from primary cultures of retinal cells selected from the group comprising the primary retinal endothelial cells and the primary retinal epithelial cells, comprise a nucleic acid fragment containing at least one immortalizing fragment of a heat-sensitive viral oncogene, which nucleic acid fragment may be associated with at least one selection gene, and exhibit the morphological characteristics and at least the surface antigen expression characteristics of the corresponding primary culture cells.
REFERENCES:
Joseph P. Hammang et al, "Immortalized Retinal Neurons Derived From SV40 T-Antigen-Induced Tumors in Transgenic Mice", Neuron, vol. 4, No. 5, pp. 775-782, May 1990.
K. Dutt et al, "Establishment of Human Retinal Pigment Epithelial Cell Lines by Oncogenes", Oncogene, vol. 5, No. 2, pp. 195-200, Feb. 1990.
K. Dutt et al, "Establishment of a Human Retinal Cell Line by Transfection of SV40 T Antigen Gene with Potential to Undergo Neuronal Differentiation", DNA and Cell Biology, vol. 13, No. 9, pp. 909-921, Sep. 1994.
K. Dutt et al, "Proto-Oncogene Expression in cAMP and TPA-Mediated Neuronal Differentiation in a Human Retinal Cell Line KGLDMSM", Current Eye Research, vol. 15, No. 5, pp. 477-485, May 1996.
Adamson Peter
Greenwood John
Lund Raymond
Brown University Research Foundation
Elrifi Ivor R.
Prince John T.
Yucel Remy
LandOfFree
Immortalized retinal cell lines and their applications does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immortalized retinal cell lines and their applications, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immortalized retinal cell lines and their applications will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2035565