Immortalized intestinal epithelial cell lines

Details Immortalized intestinal epithelial cell lines Immortalized intestinal epithelial cell lines

1994-11-18

1998-09-22

Ketter, James S.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4353201, C12N 510, C12N 1586

Patent

active

058112812

ABSTRACT:
Novel intestinal epithelial cell lines having stably incorporated heterologous DNA having a temperature-sensitive mutant oncogene are described, wherein the cell line proliferates at permissive temperatures in a conditionally immortalizing phenotype; and ceases to proliferate at nonpermissive temperatures thereby effecting cessation of cell proliferation and a differentiated intestinal epithelial cell phenotype including expression of certain brush border enzymes, and keratin markers.

REFERENCES:
Whitehead et al., PNAS, vol. 90, Jan. 1993, pp. 587-591.
Jat et al., Mol. Cell. Biol., vol. 9, 1989, pp. 1672-1681.
Chastre et al., J. Biol. Chem., vol. 266, 1991, pp. 21239-21246.
Wyllie et al., Cancer Res., vol. 52, 1992, pp. 2938-2945.

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