Chemistry: molecular biology and microbiology – Vector – per se
Patent
1996-03-07
1998-09-22
Railey, II, Johnny F.
Chemistry: molecular biology and microbiology
Vector, per se
4351722, 4351723, 435325, C12N 510, C12N 1563, C12N 1579, C12N 1587
Patent
active
058112979
ABSTRACT:
Extended life hematopoietic cell lines include stromal cell lines useful for the in vitro maintenance of undifferentiated pluripotent hematopoietic stem cells. Undifferentiated and differentiated immortalized stem cells are suitable for bone marrow transplantation, gene therapy and cell therapy applications, and as an in vitro model system for drug discovery and toxicological testing.
REFERENCES:
Bouaboula et al., Leukemia 10:505-513 (1996).
Roux et al., Oncogene 6(11):2155-2160 (1991).
Verfaillie, C.M., "Soluble factor(s) produced by human bone marrow stroma increase cytokine-induced proliferation and maturation of primitive hematopoietic progenitors while preventing their terminal differentiation", Blood 82: 2045-2053 (1993).
Roecklein, B.A., and Torok-Strob, B., "Functionally distinct human marrow stromal cell lines immortalized by transductioin with the human papilloma virus E6/E7 genes", Blood 85: 997-1005 (1995).
Rafii, S., et al., "Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors", Blood 85:3353-3363 (1995).
Mulligan, R.C., "The basic science of gene therapy", Science 260: 926-932 (1993).
Coulombel, L., et al., "Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer", Blood 62: 291-297 (1983).
Berardi, A.C., et al., "Functional isolation and characterization of human hematopoietic stem cells", Science 267: 104-108 (1995).
Garcia-Bustos, J., et al., "Nuclear protein localization", Biochem. Biophys. Acta 1071: 83-101 (1991).
Raikhel, N., "Nuclear targeting in plants", Plant Physiol. 100: 1627-1632 (1992).
Citovsky, V., et al., "Nuclear localization of agrobacterium VirE2 protein in plant cells", Science 256: 1802-1805 (1992).
Sadler et al., "A Yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology ot DnaJ, an Escherichia coli heat shock protein", J. Cell Biol. 109: 2665-2675 (1989).
Okada, C.Y. and Rechsteiner, M., "Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles", Cell 29: 33-41 (1982).
Takai, T., et al., "DNA transfection of mouse lymphoid cells by the combination of DEAE-dextran-mediated DNA uptake and osmotic shock procedure", Biochem. Biophys. Acta 1048: 105-109 (1990).
Michael, S.I., et al., "Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway", J. Biol. Chem. 268: 6866-6869 (1993).
Naruyama et al., P.N.A.S. (USA) 87: 5744 (1990).
Rhim, J.S., et al., "Neoplastic transformation of human keratinocytes by polybrene-induced DNA-mediated transfer of an activated oncogene", Oncogene 4: 1403-1409 (1989).
La Thangue, N.B., "DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control", Trends in Biochem. Sci. 19: 108-114 (1994).
Rafii, S., et al., "Isolation and Characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion", Blood 84: 10-19 (1994).
Johnson, D.G., et al., "Expression of transcription factor E2F1 induces quiescent cells to enter S phase", Nature 365: 349-352 (1993).
Singh, P., et al., "Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation", EMBO Journal 13: 3329-3338 (1994).
Caux, C., et al., "GM-CSF and TNF-.alpha. cooperate in the generation of dendritic Langerhans cells", Nature 360: 258-261 (1992).
Caux, C., et al., "Activation of human dendritic cells through CD40 cross-linking", J. Exp. Med. 180: 1263-1272 (1994).
Schwarzbaum, S., et al., "The generation macrophage-like cell lines by transfection with SV40 origin defective DNA", J. Immunol. 132: 1158-1162 (1984).
Cameron, P.U., et al., "Dendritic cells exposed to human immunodeficiency virus Type-1 transmit a vigorous cytopathic infection to CD4.sup.+ T cells", Science 257: 383-387 (1992).
Pope, M., et al., "Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1", Cell 78: 389-398 (1994).
Berliner, N., et al., "Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in nuetrophil-specific gene expression", Blood 85: 799-8032 (1995).
Bartley, T.D., et al., "Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl", Cell 77: 1117-1124 (1994).
de Sauvage, F.J., et al., "Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand", Nature 369: 533-538 (1994).
Lok, S., et al., "Cloning and expression of muring thrombopoietin cDNA and stimulation of platelet production in vivo", Nature 369: 565-568 (1994).
Rennick, D., et al., "Cofactors are essential for stem cell factor-dependent growth and maturation of mast cell progenitors: comparative effects of interleukin-3 (IL-3), IL-4, IL-10,and fibroblasts", Blood 85:57-65 (1995).
Graber, N., et al., "T cells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1", J. Immunol. 145: 819-830 (1990).
Puleo, D.A., and Huh, W.W., "Acute toxicity of metal ions in cultures of ostogenic cells derived from bone marrow stromal cells", J. Applied Biomaterials 6: 109-116 (1995).
Gandhi, G., et al., "Genotoxic effects of deltamethrin in the mouse bone marrow micronucleus assay", Mut. Res. 346: 203-206 (1995).
Bhalla, K., et al., "2'-dexoycytidine protects normal human bone marrow progenitor cells in vitro aganist the cytotoxicity of 3'-azido-3'-deoxythymidine with preservation of antiretroviral activity", Blood 74: 1923-1928 (1989).
Mackay, J.M., et al., "Trichloroacetic acid: investigation into the mechanism of chromosomal damage in the in vitro human lymphocyte cytogenetic assay and the mouse bone marrow micronucleus test", Carcinogenesis 16: 1127-1133 (1995).
Chan, T.C.K., et al., "Antiviral nucleoside toxicity in canine bone marrow progenitor cells and its relationship to drug permeation", Eur. J. Haematol. 49: 71-76 (1992).
AMBA Biosciences LLC
Railey II Johnny F.
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