Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Rodent cell – per se
Reexamination Certificate
2005-10-31
2008-08-19
Nguyen, Quang (Department: 1633)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Rodent cell, per se
C435S354000, C435S325000
Reexamination Certificate
active
07413900
ABSTRACT:
Aspects of the invention provide an immortalized fibroblast cell line capable of the growth and maintenance of human embryonic stem cells. An immortalized fibroblast cell line derived from an early stage mouse embryo is provided. Methods of preparing an immortalized fibroblast cell line from an early stage mouse embryo are also provided.
REFERENCES:
patent: 5284755 (1994-02-01), Gearing et al.
patent: 5453357 (1995-09-01), Hogan
patent: 5843780 (1998-12-01), Thomson
patent: 6200806 (2001-03-01), Thomson
patent: 2002/0072117 (2002-06-01), Xu et al.
patent: 2003/0017589 (2003-01-01), Mandalam et al.
patent: 2005/0148070 (2005-07-01), Thomson et al.
patent: 2005/0153445 (2005-07-01), Mandalam et al.
Todaro et al. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17:299-313,1963.
Park et al. Establishment and maintenance of human embryonic stem cells on STO, a permanently growing cell line. Biol. Reprod. 69:2007-2014, 2003.
Boiani et al., Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev. May 15, 2002;16(10):1209-19.
Green et al., Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci USA. Nov. 1979;76(11):5665-8.
Green, H. et al., Marker succession during the development of keratinocytes from cultured human embryonic stem cells. Proc Natl Acad Sci USA Dec. 23, 2003;100(26):15625-30. Epub Dec. 8, 2003.
Iuchi et al., Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamine. Proc Natl Acad Sci USA. Mar. 4, 2003;100(5):2409-14. Epub Feb. 18, 2003.
Matin et al., Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells. Stem Cells. 2004;22(5):659-68.
Nichols et al., Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. Oct. 30, 1998;95(3):379-91.
Niwa et al., Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet. Apr. 2000;24(4):372-6.
Pesce et al., Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells. 2001;19(4):271-8. Review.
Rheinwald et al., H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell. Nov. 1975;6(3):331-43.
Robertson et al., Embryo-derived stem cell lines. From: Teratocarcinomas and Embryonic Stem Cells: A Pratical Approach. E. J. Robertson, Oxford, UK. IRL Press. 1987:71-112.
Scholer. et al., A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J. Sep. 1989;8(9):2543-50.
Scholer et al., Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. Jul. 1990;9(7):2185-95.
Scholer et al., Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J. Sep. 1989;8(9):2551-7.
Scholer, Octamania: the POU factors in murine development. Trends Genet. Oct. 1991;7(10):323-9.
Schuldiner et al., Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci USA. Oct. 10, 2000;97(21):11307-12.
Shamblott et al., Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro. Proc Natl Acad Sci U S A. Jan. 2, 2001;98(1):113-8.
Thomson et al., Embryonic stem cell lines derived from human blastocysts. Science. Nov. 6, 1998;282(5391):1145-7. Erratum in: Science Dec. 4, 1998;282(5395):1827.
Thomson et al., Human embryonic stem cell and embryonic germ cell lines. Trends Biotechnol. Feb. 2000;18(2):53-7.
Thomson et al., Isolation of a primate embryonic stem cell line. Proc Natl Acad Sci USA. Aug. 15, 1995;92(17):7844-8.
Velkey et al., Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. Genesis. Sep. 2003;37(1):18-24.
Ware et al., Inherited resistance to N- and B-tropic murine leukemia viruses in vitro: evidence Virology. Nov. 1972;50(2):339-48.
Zhang et al., Embryonic mouse STO cell-derived xenografts express hepatocytic functions in the livers of nonimmunosuppressed adult rats. Stem Cells. Feb. 2005;23(2):186-99.
Green Howard
Iuchi Shiro
Kuri-Harcuch Walid
Marsch-Moreno Meytha
Nguyen Quang
President and Fellows of Harvard College
Wolf Greenfield & Sacks
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