Immortalized dendritic cells

Details Immortalized dendritic cells Immortalized dendritic cells

1995-06-07

1997-07-15

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 29, 4351721, 4351723, 435325, 435355, C12Q 168, C12Q 102, C12N 502, C12N 1512

Patent

active

056482191

ABSTRACT:
The present invention provides an immature dendritic cell line derived from p53 growth suppressor gene deficient animals. The immature dendritic cell line may be induced to become an activated dendritic cell line that will stimulate T-cells to proliferate. The cell line is useful for presentation of antigens involved in autoimmune disease and analysis of peptides that produce a T-cell response.

REFERENCES:
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Lutz et al., J. Immunol. Methods 174: 269-279, 1994.
Girolomoni et al., Eur. J. Dermatol. 5: 12-15, 1995.
Inaba et al., J. Exp. Med. 176: 1693-1702, 1992.
Paglia et al., J. Exp. Med. 178: 1893-1901, 1993.
O'Doherty et al., J. Exp. Med. 178: 1067-1078, 1993.
Harvey et al., Oncogene 8: 2457-2467, 1993.
Tsukada et al., Oncogene 8: 3313-3322, 1993.
Karlhofer et al., J. Exp. Med. 181: 1785-1795, 1995.

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