Immortalization of dendritic cells with v-myc oncogene

Details Immortalization of dendritic cells with v-myc oncogene Immortalization of dendritic cells with v-myc oncogene

1998-01-02

2000-12-05

Hauda, Karen M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435375, 435324, 435343, 4353431, 4353432, 435344, C12N 500, C12N 1563, C12N 510, A61K 4800

Patent

active

061563072

ABSTRACT:
The present invention refers to immortalized dendritic cells, to a process for their production from primary cultures and to their use for the activation, in vivo or in vitro, of T lymphocytes in antigen specific way.

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patent: 5648248 (1997-07-01), Zenke et al.
Martin F. Bachmann et al., "Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8.sup.+ cytotoxic T lymphocytes", Eur. J. Immunol., 1996, vol. 26, pp. 2595-2600.
Shin Komatsubara et al, "Immortalization of Murine Leukocytes by Oncogenes. I. Attempts to Immortalize Splenic Dendritic Cells Resulted in the Production of Nondendritic Transformant Cells", Mem. Fac. Sci. Kyoto Univ. (Ser. Biol.), Jul. 1988, vol. 12, pp. 31-39.
Zhenhai Shen et al, "Cloned Dendritic Cells Can Present Exogenous Antigens on Both MHC Class I and Class II Molecules", The Journal of Immunology, 1997, vol. 158, pp. 2723-2730.
Giampiero Girolomoni et al, "Establishment of a cell line with features of early dendritic cell precursors from fetal mouse skin", Eur. J. Immunol., 1995, vol. 25, pp. 2163-2169.
M. Janitz et al, "Polymorphic MHC class II promoters exhibit distinct expression pattern in various antigen-presenting cell lines", Tissue Antigens, 1997, vol. 49, pp. 99-106.
Manfred B. Lutz et al, "Different cytokines regulate antigen uptake and presentation of a precursor dendritic cell line", Eur. J. Immunol., 1996, vol. 26, pp. 586-594.
Komatsubara et al. "Immortalization of Murine Leukocytes by Oncogenes," Microbiol. Immunol., vol. 32(8):869-875, 1988.
Orkin et al. Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, NIH Report and Recommendation, Dec. 7, 1995.
Williams et al. "Isolation and Function of Human Dendritic Cells," International Review of Cytology, vol. 153: 41-103, 1994.
Paglia et al. "Immortalized Dendritic Cell Line Fully Competent in Antigen Presentation Initiates Primary T-cell Responses in vivo," J. Exp. Med., vol. 178: 1893-1901, Dec. 1993.

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