Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1989-02-28
1991-06-25
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 32, 4351721, 4352401, 4352402, 436 63, 436813, C12Q 102, C12Q 118, C12N 506
Patent
active
050266373
ABSTRACT:
Immortalized human epithelial cell sublines are provided. The novel cell lines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The novel cells exhibit positive reactivity with milk-fat globule membrane antigen and cytokeratin anti-serum. The cells are non-tumorigenic in athymic mice, and exhibit both three-dimensional growth in collagen and dome formation in confluent cultures. The cell sublines demonstrate growth control by hormones and growth factors. The novel cell sublines are useful in evaluating the capacity of preselected agents to bring about a change in epithelial cell growth and in the production of proteins.
REFERENCES:
Jones et al., Breast Cancer Research Group and Pathology Dept., Michigan Cancer Foundation, Detroit, Mich. 48201, Proceedings of AACR, vol. 29, (Mar. 1988).
In Vitro, vol. 20, No. 8, Aug. 1984, "Calcium Regulation of Normal Human Mammary Epithelial Cell Growth in Culture", Charles M. McGrath and Herbert D. Soule, pp. 653-662.
In Vitro Cellular & Developmental Biology, vol. 33, No. 1, Jan. 1986, "A Simplified Method for Passage and Long-Term Growth of Human Mammary Epithelial Cells", Herbert D. Soule and Charles M. McGrath, pp. 6-12.
Proceedings of AACR, vol. 29, Mar. 1988, #1780, p. 448.
McGrath Charles M.
Soule Herbert
Gossett Dykema
Kelly Robert L.
Kepplinger Esther L.
Scheiner Toni R.
LandOfFree
Immortal human mammary epithelial cell lines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immortal human mammary epithelial cell lines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immortal human mammary epithelial cell lines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1039513