Immortal human mammary epithelial cell lines

Details Immortal human mammary epithelial cell lines Immortal human mammary epithelial cell lines

1991-05-20

1995-07-25

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352401, C12N 500, C12N 508

Patent

active

054361524

ABSTRACT:
Immortalized human epithelial cell sublines are provided. The novel cell lines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The novel cells exhibit positive reactivity with milk-fat globule membrane antigen and cytokeratin anti-serum. The cells are non-tumorigenic in athymic mice, and exhibit both three-dimensional growth in collagen and dome formation in confluent cultures. The cell sublines demonstrate growth control by hormones and growth factors. The novel cell sublines are useful in evaluating the capacity of preselected agents to bring about a change in epithelial cell growth and in the production of proteins.

REFERENCES:
patent: 4423145 (1983-12-01), Stampfer et al.
patent: 4808532 (1989-02-01), Stampfer
patent: 5026637 (1991-06-01), Soule et al.
In Vitro, vol. 20, No. 8 Aug. 1984, "Calcium Regulation of Normal Human Mammary Epithelial Cell Growth In Culture," Charles M. McGrath and Herbert D. Soule, pp. 635-662.
In Vitro Cellular & Developmental Biology, vol. 33, No. 1, Jan., 1986, "A Simplified Method For Passage And Long-Term Growth of Human Mammary Epithelial Cells," Herbert D. Soule and Charles M. McGrath, pp. 6-12.
Jones et al., Proceedings of AACR vol. 29 Mar. 1988, #1780, p. 448.

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