Immobilized immunoglobulin-binding proteins

Details Immobilized immunoglobulin-binding proteins Immobilized immunoglobulin-binding proteins

1992-02-18

1993-11-09

Wax, Robert A.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530402, 530413, 436532, C07K 1706

Patent

active

052603733

ABSTRACT:
The invention concerns unique immobilized immunoglobulin-binding protein materials which have a high binding capacity for immunoglobulins. Exemplified are preparations which have a high binding capacity for IgGl immunoglobulins. The preparations are made by covalently joining an immobilization support material to (a) an arginine-containing linker and (b) an immunoglobulin-binding protein material. The immunoglobulin-binding protein can be joined to the linker through an amide bond. Specifically disclosed is an immobilized protein A preparation. This immobilized protein A preparation has utility in the art of purifying monoclonal antibodies.

REFERENCES:
patent: 3995018 (1976-11-01), Sjoquist
patent: 4217338 (1980-08-01), Quash
patent: 4536479 (1985-08-01), Vander-Mallie
patent: 4690905 (1987-09-01), Diamond
patent: 5089605 (1992-02-01), Profy et al.
Campbell, A. M. 1986, "Monoclonal Antibody Technology; The production and characterization of Rodent and Human Hybridomas" in Laboratory Techniques in Biochemistry and Molecular Biology, Burden et al (eds.), Elsevier, N.Y., vol. 13, 1986, pp. 180-183.

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