Immobilized immunoadsorbent

Details Immobilized immunoadsorbent Immobilized immunoadsorbent

1975-04-07

1977-11-22

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

23230B, 1951035A, 260 6, 260 8, 424 1, 424 8, 424 13, 424 78, G01N 3100, G01T 100, G21C 1700

Patent

active

040596850

ABSTRACT:
An immobilized immunoadsorbent for use in immunoassay and radioimmunoassay procedures includes, in a preferred form, a mass of superficially porous refractory particles having a water insoluble polymer, such as dextran, bonded thereto. The polymer in turn has bonded to it, by covalent bonds, antibodies capable of binding a specific antigen thereto and stoichiometrically releasing the bound antigen by the use of a rinsing solution which does not adversely affect the binding of the antibody to the polymer. Preferably, each of the porous particles includes an impervious core which has joined thereto sufficient layers of microparticles to form an outer porous coating on the core. Methods of forming such an immunoadsorbent and for using the same and structure for supporting the same are also disclosed.

REFERENCES:
patent: 3505785 (1970-04-01), Kirkland
patent: 3639558 (1972-02-01), Czizmas
patent: 3652761 (1972-03-01), Weetall
patent: 3700609 (1972-10-01), Tregear
patent: 3796634 (1974-03-01), Haynes
patent: 3975511 (1976-08-01), Vann

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