Immobilized enzyme membrane for a semiconductor sensor

Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...

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204403, 435180, 435288, 435817, C12N 1104, C12N 1108, C12M 140, G01N 2726

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active

048943398

ABSTRACT:
A membrane containing an immobilized enzyme for a semiconductor sensor is prepared containing a water soluble photosensitive resin including a high molecular weight polyvinyl pyrrolidone crosslinked to 2, 5-bis (4'-azide-2'-sulfobenzal) cyclopentanone sodium salt, and an enzyme. Glutaraldehyde and bovine serum albumin, polyamino acid or polyamino amino acid copolymer may also be present to provide chemical crosslinking. The enzyme may be glucose oxidase, urease or lipase. The membrane can be directly formed on ion-sensitive protions of a pH-ion sensitive field effect transistor to form a semiconductor sensor by coating an aqueous solution of the resin and enzyme on the ion-sensitive portion, drying and irradiating with light such as ultraviolet light to provide photo crosslinking.

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patent: 4631249 (1986-12-01), Kalyanaraman
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"Application of Water Soluble Photo-Crosslinkable Polymer to Enzyme Membrane for FET-Biosensor", Proceedings of the Second International Meeting on Chemical Sensors, Bordeaux, France, Aucouturier, editor, pp. 576-579 (Jul. 7-10, 1986) Hanazato et al.
"Glucose Sensor Based on a Field-Effect Transistor with a Photolithographically Patterned Glucose Oxidase Membrane", Analytica Chimica Acta, 193 pp. 87-96 (1987), Hanazato et al.
"Formation of an Enzyme Immobilized Membane . . . ", Shimoide et al, Denki Gakkai Kenkyuukai Shiryou (Electric Society Research Material) (EIM-85-48 to 56, EFM-85-27 to 35), May, 1985.
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