Immobilized cyclophilin and methods of using such

Details Immobilized cyclophilin and methods of using such Immobilized cyclophilin and methods of using such

1987-06-23

1991-09-10

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

530408, 530409, 530411, 530412, 530413, 530350, 530810, 530812, 530813, 530814, 530815, 436501, 436503, 436518, 436528, 436529, 436530, 436531, 436532, 430161, 430824, C07K 1712, G01N 33566, G01N 3353

Patent

active

050475126

ABSTRACT:
Homogeneous cyclophilin, a soluble binding protein, having a specific binding activity of above 50 ug cyclosporin A per mg protein and a molecular weight of about 17,600 daltons, reversibly binds immunosuppressants or antibodies thereto such as cyclosporin or anti-cyclophilin. It is isolated from the cytosol of several different mammalian tissues and can be used in various diagnostic and purifications procedures.

REFERENCES:
Handschumacher et al., Science, 726, 1984, pp. 544-547.
Parukh et al., Cand EN, Aug. 1985, pp. 11-32.
Janson, Trends in Biotechnology 1984, vol. 2(2), pp. 31-38.

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