Immobilized biological membranes

Details Immobilized biological membranes Immobilized biological membranes

1997-11-21

1999-07-06

Nutter, Nathan M.

Stock material or miscellaneous articles

All metal or with adjacent metals

Component of composite having metal continuous phase...

428594, 428615, 428623, 428624, 428936, 428938, 427 21, B22F 326, B32B 1500, B21D 3900

Patent

active

059195762

ABSTRACT:
A composition comprising an immobilized biological membrane is provided. The functional immobilized biological membrane consists of a support structure, a metal layered onto a surface of the support structure, an alkanethiol monolayer assembled onto the metal, and a biological membrane deposited on the alkanethiol monolayer. Also provided is a method of producing the immobilized biological membrane, wherein the method involves contacting an alkanethiol with a metal surface of a support structure in forming an alkanethiol monolayer assembled onto the metal, and depositing a biological membrane onto the alkanethiol monolayer such that the biological membrane becomes associated with the alkanethiol monolayer. Uses of the biological membrane include as a sensing indicator in a biosensor, as an adsorbent in a chromatography system, and as a coating for medical devices.

REFERENCES:
patent: 5728590 (1998-03-01), Powell
Plant, Gueguetchkeri and Yap, "Supported Phospholipid/Alkanethiol Biomimetic Membranes: Insulating Properties", Biophysical Journal, 1994, vol. 67, pp. 1126-1133.

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