Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1984-01-09
1990-01-23
Warden, Robert J.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436514, 436541, 436546, 436161, 436172, 436177, 436178, 436800, 436807, 436808, 436824, 422 68, 422 69, 422 70, G01N 33543, G01N 33558, G01N 22538, G01N 3002
Patent
active
048958093
ABSTRACT:
A method and apparatus for quantitatively analyzing, in a flowing stream, materials in a biological or chemical sample utilizes immobilized antobodies reversibly precharged with fluorescently labeled antigens. The labeled antigens are competitively displaced by unlabeled antigens in the sample, after the sample antigens have been segregated into zones by a chromatographic device, such as the reverse phase high performance liquid chromatograph. Displaced labeled antigens are measured by a fluorescence detector. A plurality of antibody species may be concurrently utilized, thereby allowing quantification of a plurality of antigens from a single sample.
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Regnier, Science, vol. 222, No. 4621, 245-252, 1983.
Regnier Fred E.
Schlabach Timothy D.
Cole Stanley Z.
Fisher Gerald M.
Schnapf David
Spiegel Jack
Varian Associates Inc.
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