Immobilized antibodies

Details Immobilized antibodies Immobilized antibodies

1988-11-14

1990-08-14

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530815, 530816, 436531, 436532, C08H 100, C08L 8900, A61K 3514

Patent

active

049488368

ABSTRACT:
Antibodies which are immobilized and covalently bound to a matrix polymer by means of a modification in a carbohydrate region of the antibodies; wherein the binding of the antibodies is effected by condensing at least one aldehyde group in an oxidized carbohydrate region and at least one epoxide function of an epoxy-group-containing matrix polymer, said condensation being conducted in the presence of a bifunctional reagent which has, on one end position of a spacer unit having at least three members, an amino group capable of condensing with the aldehyde group, and which has on the other end position a group which reacts covalently with the epoxide function.

REFERENCES:
patent: 4210723 (1980-07-01), Dorman et al.
patent: 4511694 (1985-04-01), Kramer et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4874813 (1989-10-01), O'Shannessy
patent: 4889916 (1989-12-01), Packard et al.
O'Shannessy et al., "Specific Conjugation Reactions of the Oligosaccharide Moieties of Immunoglobulin" Journal of Applied Biochemistry 7,347-355 (1985).

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