Immobilized acetylcholinesterase stabilized by a film of gelatin

Details Immobilized acetylcholinesterase stabilized by a film of gelatin Immobilized acetylcholinesterase stabilized by a film of gelatin

1995-03-16

1997-04-29

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435 20, 435176, 435180, C12N 1102, C12N 1114, C12N 1108, C12Q 146

Patent

active

056248318

ABSTRACT:
Acetylcholinesterase and/or a receptor of acetylcholinesterase is immobilized on a solid support and stabilized by covering with a protective film of gelatin and/or albumin containing trehalose. The film is applied by covering the immobilized acetylcholinesterase and/or receptor of acetylcholinesterase with a layer of a gel-forming solution of gelatin or albumin in an evaporable solvent containing dissolved trehalose, and evaporating the solvent to leave the film. The film provides stability against dry heat, organic solvents, proteases and changes in pH. Other additives such as polyhydric alcohols, organic solvents, polymers and/or ionic and non-ionic components may be present to increase stabilization. A diagnostic kit or chromatography column may be formed containing the stabilized immobilized acetylcholinesterase and/or receptor of acetylcholinesterase.

REFERENCES:
patent: 4324858 (1982-04-01), Goodson et al.
patent: 4689297 (1987-08-01), Good et al.

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