Immobilization of specific binding assay reagents

Details Immobilization of specific binding assay reagents Immobilization of specific binding assay reagents

1994-10-28

1999-01-19

Ceperley, Mary E.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

435 793, 435 794, 435817, 435823, 436500, 436505, 436512, 436530, 5303911, 530811, G01N 33552, G01N 3378

Patent

active

058613196

ABSTRACT:
Methods and compositions are provided for specific binding assays in which specific binding reagents are immobilized on a solid phase. Immobilization is facilitated by covalently coupling specific binding assay reagents such as polypeptide receptors or analytes with water soluble polymers. Such water soluble polymers, for example star polymers such as dendrimers, provide production advantages of lot-to-lot uniformity and homogeneity, and can enhance sensitivity due to low non-specific binding to the solid phase.

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