Immobilization of proteins with polyurethane polymers

Details Immobilization of proteins with polyurethane polymers Immobilization of proteins with polyurethane polymers

1976-11-18

1978-07-04

Naff, David M.

Textiles: fiber preparation

195 63, 195DIG11, 260 6, 260112R, C07G 700, C07G 702

Patent

active

040986454

ABSTRACT:
A protein which can be an enzyme is immobilized by: (a) admixing the protein and an isocyanate-capped liquid polyurethane prepolymer in the absence of water to form a resulting mixture (an intermediate product); and (b) forming the intermediate product by reacting it with water to form a polyurethane foam comprising the immobilized enzyme. When certain proteins in sufficient amount are mixed with the prepolymer in the absence of water the resultant protein prepolymer mixture will solidify to produce a solid non-foamed product containing a protein immobilized therein. Initially mixing the protein and prepolymer in the absence of water results in immobilization of a substantially greater amount of protein than when water is present.

REFERENCES:
patent: 3672955 (1972-06-01), Stanley
patent: 3802997 (1974-04-01), Messing
patent: 3905923 (1975-09-01), Klug
patent: 3928138 (1975-12-01), Wood et al.
Bartling et al., Protein Modification in Nonaqueous Media, Biotechnology and Bioengineering, vol. XVI, 1974, (pp. 361-369).
Olson et al., Immobilized Enzymes in Food and Microbial Processes, Plenum Press, N. Y., 1974, (pp. 35-38).
Hustad et al., Immobilization of Beta-Galactosidase on an Insoluble Carrier With a Polyisocanate Polymer, I. Preparation and Properties, J. Da. Sci., vol. 56, No. 9, 1973 (pp. 1111-1117).
Arrameas et al., The Cross-Linking of Proteins With Glutanaldehyde and its use for the Preparation of Immunoadsorbents, Immunochemistry, vol. 6, 1969 (pp. 53-66).

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