Immobilization of peptide-containing compounds on metal hydroxid

Details Immobilization of peptide-containing compounds on metal hydroxid Immobilization of peptide-containing compounds on metal hydroxid

1988-09-09

1990-01-30

Naff, David M.

Chemistry: natural resins or derivatives; peptides or proteins;

Carrier - bound or immobilized peptides or proteins and the...

Peptides or proteins is immobilized on, or in, an inorganic...

435176, 436524, 436527, C07K 1714, C12N 1114, G01N 33551, G01N 33552

Patent

active

048974684

ABSTRACT:
Peptide-containing compounds such as enzymes, antibodies and antigens are immobilized on metal hydroxy gels formed by hydrolysis of metal alkoxides in an aqueous solvent while evaporating off the solvent. Preferably, hydrogen fluoride is present in the solvent during hydrolysis to provide a fluoride-substituted metal hydroxy gel. Water containing lower alcohol is a preferred solvent. The gel is treated with a coupling agent and a peptide-containing compound is chemically bonded to the gel.

REFERENCES:
patent: 3948806 (1972-06-01), Miller
patent: 4148689 (1979-04-01), Hino et al.
patent: 4243692 (1981-01-01), Scholze et al.
patent: 4461832 (1984-07-01), Tschang et al.

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