Immobilization of lipases by entrapment in silica matrices

Details Immobilization of lipases by entrapment in silica matrices Immobilization of lipases by entrapment in silica matrices

1998-06-12

2000-06-27

Naff, David M.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435134, 435135, 435176, 435182, G03B 3700

Patent

active

060804025

ABSTRACT:
Lipases are immobilized by entrapment in silicon-containing matrices obtained by hydrolysis of alkoxy-silicon compounds in the presence of a catalyst and additives such as proteins, polyhydroxy compounds, insoluble organic polymers and/or insoluble inorganic compounds. The entrapped lipase may be used for treatment of digestive insufficiency in a patient caused by pancreatic disease or cystic fibrosis.

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Derwent Japio Abstract 85-164486 J60164486 (Aug. 1985) Seto, et al. "Method for immobilizing Lipase for ester interchange".
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Biotech. Abs. 95-15425 Kawakami et al. Biotech. Tech. (1995) 9, 10, 701-704 "Sol-gel entrapment of lipase . . . ".

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