Immobilization of biologically active substances

Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an...

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435181, 435182, C12N 1114, C12N 1106, C12N 1104

Patent

active

044254342

ABSTRACT:
The invention relates to a method for the preparation of discrete particles containing a biologically active substance comprising discrete particles of support material having immobilized in the pores thereof a biologically active substance (e.g. an enzyme). The method includes precipitating a biologically active substance in the pores of the particles of support material, by use of a precipitating agent comprising or including a water miscible organic liquid, and treating the biologically active substance precipitated in the pores to cause cross-linking so as to immobilize biologically active substance in the pores of the particles or porous support material.

REFERENCES:
patent: 3736231 (1973-05-01), Stanley et al.
patent: 3804719 (1974-04-01), Messing
patent: 3838007 (1974-09-01), Van Velzen
patent: 4182655 (1980-01-01), Hartmeier
patent: 4323650 (1982-04-01), Roserear
Olson et al., Immobilized Enzymes in Food and Microbial Processes, Plenum Press, N.Y., 1974 (pp. 54-61).

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