Immobilization of biologically active protein on a support with

Details Immobilization of biologically active protein on a support with Immobilization of biologically active protein on a support with

1993-03-25

1995-04-11

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

435176, 435181, 436518, 436524, 436532, 530810, 530811, 530816, C12N 1100, C12N 1106, C12N 1114, G01N 33549

Patent

active

054057663

ABSTRACT:
Enzymes and certain other bioactive substances are immobilized on solid substrates which have sufficient functional groups such as hydroxyl or carboxyl. The bioactive substances are linked to the substrates through spacer compounds having a long open alkyl chain with 7-18 carbon atoms and also through phospholipid intermediates. The spacer compound is chemically linked to the substrate. The phospholipid is covalently linked to the spacer compound. Immobilized bioactive substances of the invention exhibit a marked increase in activity and stability. In a preferred embodiment, immobilized enzymes having a high degree of resistance to thermal inactivation are prepared.

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Kallury, et al., Analytica Chimica Acta, vol. 225, 1989, pp. 369-389.

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