Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1992-10-19
1994-09-20
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
424422, 424423, 435180, 435181, 514822, C12N 1104, C12N 1106, C12N 1108, A61F 1300
Patent
active
053488733
ABSTRACT:
An anti-thrombogenic substance is immobilized on a base of a medical device to impart anti-thrombogenic properties to the medical device. The method comprises the steps of applying a photo-reactive azide derivative macromolecular material to a base to form a bonding layer, coating the bonding layer with a macromolecular layer composed of a water-soluble photo-crosslinking macromolecular material containing the anti-thrombogenic substance, and irradiating the base with ultraviolet light with the bonding layer and the macromolecular layer formed thereon to develop inter-molecular covalent bonding in the bonding layer. The macromolecular layer containing the anti-thrombogenic substance is thus fixed onto the base. Concurrently, the anti-thrombogenic substance is immobilized in the macromolecular layer which is crosslinked. The azide derivative can be poly-m-azidostyrene, copolymers, of poly-m-aziodstyrene with styrene and copolymers of poly-m-azidostyrene with methyl methacrylate. The water-soluble photo-crosslinking macromolecular material can be a copolymer of a photo-dimeric monomer with a water-soluble monomer or a copolymer of a photo-reactive azide with a water-soluble monomer.
REFERENCES:
patent: 5061750 (1991-10-01), Feijen et al.
patent: 5071909 (1991-12-01), Pappin et al.
patent: 5134057 (1992-07-01), Kuypers et al.
Matsuda Takehisa
Nakayama Yasuhide
Sugawara Takashi
K.K. Vayu
Naff David M.
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