Immediate release/sustained release compressed tablets

Details Immediate release/sustained release compressed tablets Immediate release/sustained release compressed tablets

1997-10-31

2000-10-03

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

A61K 922

Patent

active

061269697

ABSTRACT:
An orally administrable sustained-release dosage form includes particles of an active pharmaceutical ingredient which is coated with a polymeric material that is water-insoluble, but water-permeable and water-swellable, so that the sustained-release dosage form provides controlled release which is independent of certain variable physiological factors such as pH. In accordance with one aspect of the invention, the active pharmaceutical ingredient is acetaminophen and the coated acetaminophen particles are combined with uncoated acetaminophen particles to provide a combination immediate-release/sustained-release dosage form. In accordance with another aspect of the invention, the active pharmaceutical ingredient is coated with a methacrylate ester copolymer, and the coated particles are combined with uncoated particles of an active pharmaceutical ingredient to provide a combination immediate-release/sustained-release dosage form, wherein the sustained-release component provides a release rate which is substantially independent of physiological factors such as pH. The final orally administable dosage form can be appeared as compressed tablets, capsules or pouches.

REFERENCES:
patent: 3424842 (1969-01-01), Nurnberg
patent: 3629393 (1971-12-01), Nakamoto et al.
patent: 3883647 (1975-05-01), Geller
patent: 3927205 (1975-12-01), Ohno et al.
patent: 4234565 (1980-11-01), Flodin et al.
patent: 4341759 (1982-07-01), Bogentoft et al.
patent: 4439453 (1984-03-01), Vogel
patent: 4526777 (1985-07-01), Blume et al.
patent: 4574080 (1986-03-01), Roswall et al.
patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4666703 (1987-05-01), Kopf
patent: 4695467 (1987-09-01), Uemura et al.
patent: 4708874 (1987-11-01), De Haan et al.
patent: 4710519 (1987-12-01), Finnan et al.
patent: 4716041 (1987-12-01), Kj.o slashed.rnaes et al.
patent: 4724148 (1988-02-01), Sonobe et al.
patent: 4729190 (1988-03-01), Lee
patent: 4740365 (1988-04-01), Yukimatsu et al.
patent: 4748023 (1988-05-01), Tamas et al.
patent: 4765988 (1988-08-01), Sonobe et al.
patent: 4772475 (1988-09-01), Fukui et al.
patent: 4814178 (1989-03-01), Bolton et al.
patent: 4816264 (1989-03-01), Phillips et al.
patent: 4820522 (1989-04-01), Radebaugh et al.
patent: 4839177 (1989-06-01), Colombo et al.
patent: 4867984 (1989-09-01), Patel
patent: 4867987 (1989-09-01), Seth
patent: 4892742 (1990-01-01), Shah
patent: 4900557 (1990-02-01), Dell et al.
patent: 4940588 (1990-07-01), Sparks et al.
patent: 4952402 (1990-08-01), Sparks et al.
patent: 4968509 (1990-11-01), Radebaugh et al.
patent: 4971805 (1990-11-01), Kitanishi et al.
patent: 4981693 (1991-01-01), Higashi et al.
patent: 4983401 (1991-01-01), Eichel et al.
patent: 5004613 (1991-04-01), Radebaugh et al.
patent: 5011694 (1991-04-01), Nuernberg et al.
patent: 5015479 (1991-05-01), Mulligan et al.
patent: 5026709 (1991-06-01), Harwood et al.
patent: 5051262 (1991-09-01), Panoz et al.
patent: 5055306 (1991-10-01), Barry et al.
patent: 5073380 (1991-12-01), Babu et al.
patent: 5085865 (1992-02-01), Nayak
patent: 5093200 (1992-03-01), Watanabe et al.
patent: 5095054 (1992-03-01), Lay et al.
patent: 5128142 (1992-07-01), Mulligan et al.
patent: 5130140 (1992-07-01), Urban et al.
patent: 5160737 (1992-11-01), Friedman et al.
patent: 5167964 (1992-12-01), Muhammad et al.
patent: 5186943 (1993-02-01), Okada et al.
patent: 5198228 (1993-03-01), Urban et al.
patent: 5200193 (1993-04-01), Radebaugh et al.
patent: 5202159 (1993-04-01), Chen et al.
patent: 5229134 (1993-07-01), Mention et al.
patent: 5252341 (1993-10-01), Sauerbier et al.
patent: 5262169 (1993-11-01), Sauerbier et al.
patent: 5275824 (1994-01-01), Carli et al.
patent: 5275825 (1994-01-01), Okada et al.
patent: 5310558 (1994-05-01), Pozzi et al.
patent: 5316774 (1994-05-01), Eury et al.
patent: 5324717 (1994-06-01), Berglindh et al.
patent: 5324718 (1994-06-01), Loftsson
patent: 5330766 (1994-07-01), Morella et al.
patent: 5342627 (1994-08-01), Chopra et al.
patent: 5358718 (1994-10-01), Sauerbier et al.
patent: 5368861 (1994-11-01), Ushimaru et al.
patent: 5370878 (1994-12-01), Shah
patent: 5374430 (1994-12-01), Newton et al.
patent: 5378474 (1995-01-01), Morella et al.
patent: 5384130 (1995-01-01), Kamada
patent: 5489436 (1996-02-01), Hoy et al.
patent: 5500227 (1996-03-01), Oshlack et al.
patent: 5773031 (1998-06-01), Shah et al.
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