Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-04-30
1998-05-26
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514415, 514428, 548469, 548491, 548505, 548507, 548509, 548511, 548562, 564253, 564254, 564265, 564266, C07D20912, C07D20914, A61K 3140, A61K 31405
Patent
active
057565317
ABSTRACT:
The present invention provides a class of substituted indole and indene iminoxy derivatives of the formula ##STR1## which inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.
REFERENCES:
patent: 5399699 (1995-03-01), Kolasa et al.
J. A. Mitchell et al., "Cyclooxygenase-2: Regulatory and Relevance in Inflammation," Biochemical Pharmacology, vol. 50, No. 10 (1995), 1535-1542.
B. Battistini et al., Cox-1 and Cox-2: Toward the Development of More Selective NSAIDs, Drug News and Perspectives, vol. 7, No. 8 (1994) 501-512.
D. L. DeWitt et al., "The Differential of Prostaglandin Endoperoxide H Synthases-1 and -2 to Nonsteroidal Anti-Inflammatory Drugs: Aspirin Derivatives as Selective Inhibitors," Medicinal Chemistry Research, vol. 5, No. 5 (1995) 325-343.
PCT International Search Report Corresponding to PCT/US97/04981.
Brooks Clint D. W.
Craig Richard A.
Gunn David E.
Kolasa Teodozyji
Moore Jimmie L.
Abbott Laboratories
Oswecki Jane C.
Richter Johann
Yang Frank Z.
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