Iminopyrrolidinylindoles

Details Iminopyrrolidinylindoles Iminopyrrolidinylindoles

1980-11-24

1983-02-08

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424274, 424278, 42424856, 424246, C07D40306, A61K 3140

Patent

active

043728871

ABSTRACT:
N-Phenyl amidines which have diuretic, antithrombogenic, smooth muscle relaxant, anti-inflammatory and antiarrhythmic properties have been discovered. They are prepared by reacting a substituted aniline with a carboxamide selected from the group consisting of amides and lactams in the presence of phosphorus oxychloride. Typical examples of substituted N-phenyl amidines thus obtained are 5-methyl-2-(N-phenylbenzylamino)-1-pyrroline, 2-(N-phenylbenzylamino)-1-pyrroline, 3-[(N-1-pyrrolin-1-yl-p-anisidino)methyl]indole and 4,5,6,7,8,9-hexahydro-2-(N-phenylphenethylamino)-3H-azonine. Indole substituted N-phenyl amidines can be rearranged to provide iminopyrrolinidinylindoles which are useful as diuretic, antithrombogenic and smooth muscle relaxant agents. In the case of 3-[(N-1-pyrrolin-2-yl-p-anisidino)methyl]indole, the rearranged product is 3-[[2-p-methoxyphenylimino)-1-pyrrolidinyl]methyl]indole.

REFERENCES:
patent: 3501487 (1970-03-01), Poos

Affiliated with

Also associated with

Rating

Iminopyrrolidinylindoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Iminopyrrolidinylindoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Iminopyrrolidinylindoles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-49115