Iminomethylindolines

Details Iminomethylindolines Iminomethylindolines

1974-05-13

1976-01-27

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603096, 26032611, 260295C, 424246, 260244R, C07D 279.04

Patent

active

039351998

ABSTRACT:
This invention relates to a series of 1-iminomethylindolines which are analeptic agents capable of counteracting central nervous system depressant effects of pentobarbital and chloral hydrate. They also exhibit analgesic effects. This invention also relates to a process for the preparation of 1-iminomethylindolines which comprises reaction of an indoline with carboxamides selected from the group consisting of amides, lactams, symmetrical or unsymmetrical ureas and hydrazides. Typical examples of 1-iminomethylindoline derivatives are 5-acetyl-1-[2-(1-pyrrolinyl)]indoline and 1-[2-(5,5-dimethyl-1-pyrrolinyl)]indoline.

REFERENCES:
patent: 2872453 (1959-02-01), Jacob et al.
patent: 2937173 (1960-05-01), Shapiro et al.
patent: 3697553 (1972-10-01), Wu et al.
patent: 3833574 (1974-09-01), Haugwitz et al.

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