Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-08-26
1987-10-13
Chan, Nicky
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549378, 549377, 549373, 549341, 549333, 549229, 549228, C07D31714, C07D31726
Patent
active
046999868
ABSTRACT:
There is presented optically uniform .beta.-lactams of the formulae ##STR1## wherein Z is a readily cleavable acyl group, R.sup.1 is amino or a group convertible into amino, R.sup.2 is hydrogen or a readily cleavable protecting group and R.sup.3 and R.sup.4 each are a lower hydrocarbon group which optionally contains oxygen and which is attached via a carbon atom, whereby these groups can also be joined with one another to form a ring, with the proviso that R.sup.1 is a readily cleavable acylamino when R.sup.2 is hydrogen,
and the corresponding optical antipodes, their manufacture and use in the manufacture of antimicrobially-active .beta.-lactams as well as novel intermediates usable in their manufacture.
REFERENCES:
patent: 4202978 (1980-05-01), Fahrenholtz et al.
patent: 4473502 (1984-09-01), Liu et al.
Hubschwerlen Christian N.
Schmid Gerard
Chan Nicky
Hofmann-La Roche Inc.
Leon Bernard S.
Mazza Richard J.
Saxe Jon S.
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