Imino-alkyl and amino-nitrile cyano-guanidine

Details Imino-alkyl and amino-nitrile cyano-guanidine Imino-alkyl and amino-nitrile cyano-guanidine

1982-09-30

1984-04-17

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23364

Patent

active

044436130

ABSTRACT:
The invention relates to cyanoguanidine derivatives characterized by an imino-alkyl and amino-nitrile structure having the general formula: ##STR1## in which R.sub.1 is a 2-mercapto-ethyl, 2-hydroxy-ethyl, a 2-((4-methyl-5-imidazoly)thio-methyl)ethyl, or a 2-((4-methyl-5-imidazolyl)dithioformyloxy-methyl)ethyl radical, and R.sub.2 is the methyl radical. The invention relates to the manufacture of imino-methyl and amino-nitrile cyano-guanidines.
One compound of invention: N-methyl-N'-cyano-N"-imino-[2-((4-methyl-5-imidazolyl)thio-methyl) ethyl] guanidine is a histamine antagonist in the H.sub.2 receptors and inhibits the secretion of gastric acid. It can be used thereapeutically for the treatment of gastric and duodenal ulcers.

REFERENCES:
patent: 4093621 (1978-06-01), Brown et al.

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