Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1982-11-16
1985-07-09
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548539, C07D207337
Patent
active
045283826
ABSTRACT:
Novel compounds, which are aryl-pyrrolyl-imine derivatives of the Formula I ##STR1## and acid addition salts thereof are disclosed; which compounds may be prepared by the acid catalyzed condensation of an imidoyl chloride with a lower alkyl pyrrole-2-acetate; and which compounds are useful as intermediates to form by hydrolysis, the known useful ketone analogs which have anti-inflammatory and analgesic activity; and certain of which compounds have antisecretory, anti-irritable bowel, antidiarrheal and general behavior effect on the CNS properties.
REFERENCES:
patent: 3952012 (1976-04-01), Carson
patent: 4238396 (1980-12-01), Kondo et al.
patent: 4246176 (1981-01-01), Zaiko
Mills et al., Chem. Abs. 100, 67551g (1984).
Borisov et al., Chem. Abs. 94, 175005y (1981).
Annunziata et al., J. Chem. Soc., Perkins, I, p. 339 (1982).
Organic Reactions, vol. 5, Paul E. Spoerri, Chapter 9, pp. 387-412 (1949).
J. of Scientific and Indust. Research 32 (3), pp. 128-149 (1973), Sambamurthy Seshadri.
Organic Preparations and Procedures Int. 13 (2), 97-101 (1981) de Groot.
J. Org. Chem., vol. 42, No. 26, (1977)--pp. 4248-4251, Julian White and George McGillivray.
J. Chem. Soc., Perkin II, 259 (1982) White and McGillivray.
J. Hetercyclic Chem., 9, 725 (1972), Pinkerton and Thames.
J. Am. Chem. Soc., 72, 876 (1950) Pickard and Vaughan.
J. Am. Chem. Soc. 72, 5017 (1950) Pickard and Vaughan.
J. Pharm. Sci., 60, 1903 (1971) M. A. Luts.
Chem. Reviews, 63, 489 (1963) R. W. Layer.
Berch Mark L.
Levy David J.
McNeilab Inc.
LandOfFree
Imidoyl substituted pyrroles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidoyl substituted pyrroles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidoyl substituted pyrroles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-910215