Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-05-20
1994-11-08
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
514 6, C07C10352, A61K 3700
Patent
active
053628551
ABSTRACT:
An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13 mm Hg and predominantly in tetramer form. Preferably, the cross-linked hemoglobin composition has a predominant molecular weight of at least 64,000. The purified and cross-linked hemoglobin has improved cross-link stability to autoxidation and can be used as a blood substitute for mammals or as an oxygen transport fluid.
REFERENCES:
patent: 3925344 (1975-12-01), Mazur
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4777244 (1988-10-01), Bonhard et al.
patent: 4826811 (1989-05-01), Sehgal et al.
patent: 4857636 (1989-08-01), Hsia
Chemical Abstract No. 205961Q, vol. 91, No. 25, Columbus, Ohio, US, R. Pennathur DAS: "Modification of Hemoglobin A with Dimethyl Adipimidate", p. 211 (Dec. 17, 1979).
Chemical Abstract No. 162530, vol. 102, No. 19, Columbus, Ohio, US, R. J. Ferris: "The Crosslinking of Human met-hemoglobin with (c14)dimethyl Adipimidate", p. 252 (May 13, 1985).
Can J. Biochem. Cell. Biol., vol. 63, No. 3, pp. 195-203 (1985).
Feola, M., Gonzalez, H., Canizaro, P. C., Bingham, D. and Periman, P., "Development of a bovine stroma-free hemoglobin solution as a blood substitute," 1983, Surg. Gyn. Obst. 157: 399-408.
Plese, C. F., and Amma, E. L., "Circular dichroism as a probe of the allosteric R-T transformation in hemoglobins and modified hemoglobins," 1977, Biochem. Biophys. Res. Commun. 76; 691-697.
Pennathur-Das, R., Heath, R. H., Mentzer, W. C., and Lubin, B. H., "Modification of hemoglobin S with dimethyl adipimidate. Contribution of individual reacted subunits to changes in properties," 1982, Biochim. Biophys. Acta 704: 389-397.
Pennathur-Das, R., Vickery, L. E., Mentzer, W., and Lubin, B. H., "Modification of hemoglobin A with dimethyl adipimidate. Contribution of individual reacted subunits to changes in oxygen affinity," 1979, Biochim. Biophys. Acta 580: 356-365.
Garlick Robert L.
Lyle Stephen B.
Martin, Jr. Joseph P.
Corneglio Donald L.
Lee Lester L.
The Upjohn Company
Touzeau P. Lynn
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