Imidobisphosphoric acids, and use therefor

Details Imidobisphosphoric acids, and use therefor Imidobisphosphoric acids, and use therefor

1995-09-08

1998-03-31

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

562 10, A61K 3166, C07F 922

Patent

active

057338973

ABSTRACT:
Imidobisphosphoric acids, process for their preparation, and use thereof.
There are described compounds of the formula I ##STR1## in which R.sup.1 is (C.sub.1 -C.sub.10)-alkyl, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.6 -C.sub.10)-aryl or Het, each of which can be substituted by halogen, --OH, --NH.sub.2, --NH--CO--R.sup.7, --O--CO--R.sup.7 and --N--(R.sup.8).sub.2 where R.sup.7 =(C.sub.1 -C.sub.6)-alkyl and R.sup.8, independently of one another, is hydrogen or (C.sub.1 -C.sub.4)-alkyl or in which R.sup.1 is the radical of the formula II ##STR2## in which n is an integer from 3 to 10, m is zero to 3, R.sup.6, independently of one another, is (C.sub.1 -C.sub.6)-alkyl which is optionally substituted by halogen or --NH--CO--R.sup.7, where R.sup.7 =(C.sub.1 -C.sub.6)-alkyl, and X is absent or is (C.sub.1 -C.sub.10)-alkyl, and R.sup.2, R.sup.3, R.sup.4 or R.sup.5, independently of one another, are hydrogen, (C.sub.1 -C.sub.5)-alkyl, lithium, sodium, potassium or Si(R), where R=(C.sub.1 -C.sub.5) -alkyl, and their physiologically tolerable salts, a process for preparation of these compounds of the formula I and their use as pharmaceuticals in the prophylaxis and treatment of osteoporosis and hypercalcemia.

REFERENCES:
patent: 2798086 (1957-07-01), Coover et al.
Ding et al., Chemical Abstract, 108(19):663, Abstract No. 167599, `Organophosphorus compounds. XXI. Regioselective phosphorylation of ambident anions`.
Pinchuk et al., Reaction of N,N-Dichloro Amines with Phosphites and Phosphorochloridites. Translated from Zhurnal Obschei Khimii, vol.45, No. 11, pp. 2394-2396, Nov., 1975. Orginal article submitted Apr. 26, 1974.
Naumann et al., Phosphorus, Sulfur and Silicon, 91:169-177, `Synthese Von Neuen Imidobisphosphorsauren`, (1994). (In German).

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