Imide derivatives for inhibiting the production of interleukin-1

Details Imide derivatives for inhibiting the production of interleukin-1 Imide derivatives for inhibiting the production of interleukin-1

1997-07-01

1998-12-08

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

514212, 514352, 514357, 514376, 514398, 514423, 514440, 514466, 514471, 514616, 546312, 546337, 548229, 5483185, 548540, 549 77, 549439, 549496, 564152, 564155, A61K 3116, A61K 31635, C07C23300, C07D20700, C07D21300, C07D26300

Patent

active

058471235

ABSTRACT:
Imide compounds having a propioloyl group or pharmaceutically acceptable salts thereof which exhibit potent activities to inhibit the production of Interleukin 1-.beta. and also the production of Tumor Necrosis Factor .alpha.. These imide compounds are useful as a prophylactic or therapeutic agent for inhibiting the production of Interleukin 1-.beta. and the production of Tumor Necrosis Factor .alpha., typically for such diseases as chronic rheumatism, sepsis, ulcerative colitis, Crohn's disease and many other related diseases in which Interleukin 1-.beta. and/or Tumor Necrosis Factor .alpha. would participate.

REFERENCES:
patent: 5137905 (1992-08-01), Moon et al.
patent: 5231179 (1993-07-01), Terashima et al.

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