Imide derivatives

Details Imide derivatives Imide derivatives

1983-01-17

1984-04-10

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424274, 546 17, 548411, C07D21188, A61K 31445

Patent

active

044421141

ABSTRACT:
A series of spiro-imide compounds and their base salts with pharmacologically acceptable cations are disclosed. These particular compounds are useful in therapy as agents for the control of certain chronic diabetic complications. Preferred member compounds include 2,3-dihydro-spiro-[1H-indene-1,3'-pyrrolidone]-2',5'-dione, 2,3-dihydro-spiro-[1H-indene-2,3'-pyrrolidine]-2',5'-dione, 3,4-dihydro-spiro-[2H-naphthalene-1,3'-pyrrolidine]-2',5'-dione, 3,4-dihydro-spiro-[2H-naphthalene-1,3'-piperidine]-2',6'-dione, 6-chloro-2,3-dihydro-spiro-[4H-1-benzopyran-4,3'-pyrrolidine]-2',5'-dione and 6,7-dihydro-spiro-[5H-benzo(b)thiophene-4,3'-pyrrolidine]-2',5'-dione. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 3507881 (1970-04-01), Sandberg
patent: 3539575 (1970-11-01), Skorcz
patent: 3647797 (1972-03-01), Carr et al.
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4307108 (1981-12-01), Belletire et al.
Brittain et al.; Chem. Abs., vol. 98:143291e, (1983).
J. Faust et al., in the Journal of the American Pharmaceutical Association, vol. XLVI, No. 2, p. 118, (1957).

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