Imidazotriazines for use as phosphodiesterase inhibitors

Details Imidazotriazines for use as phosphodiesterase inhibitors Imidazotriazines for use as phosphodiesterase inhibitors

2005-08-30

2005-08-30

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S184000

Reexamination Certificate

active

06936609

ABSTRACT:
The invention relates to new imidazotriazines, processes for their preparation, and their use for the production of medicaments for the treatment and/or prophylaxis of neurodegenerative disorders, in particular Parkinson's disease.

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Beavo, J. A., “Cyclic Nucleotide Phosphodiesterases: Functional Implications of Multiple Isoforms”, Pharmacological Reviews, 75(4): 725-748 (Oct. 1995).
Beavo, J. A, Conti, M., and Heaslip, R. J., “Multiple Cyclic Nucleotide Phosphodiesterases”, Molecular Pharmacology, 46(3): 399-405 (Sep. 1994).
Charles, I., Latham, D. W. S., Hartley, D., Oxford, A. W., and Scopes, D. I. C., “Bicyclic Heterocycles with Nitrogen at the Ring Junction. Part 2. 1. Application of the Dakin-West Reaction to the Synthesis of Immidazo-[5,1-f]-1,2,4-triazin-4-(3H)-ones”, J. Chem. Soc., Perkin Trans. I, 5(1): 1139-1146 (May 1980).
Soderling, S. H., and Beavo, J. A., “Regulation of cAMP and cGMP Signaling: New Phosphodiesterases and New Functions”, Current Opinion in Cell Biology, 12(2): 174-179 (Apr. 2000).

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