Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-04-06
1990-07-17
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544 10, A61K 3154, C07D51304
Patent
active
049421433
ABSTRACT:
The present invention relates to 1,3,6,7-Tetrahydro-7-oxoimidazo[4,5-c][1,2,6]-thiadiazine 2-oxide derivatives of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are the same or different and represent an alkyl group, an aryl group or an aralkyl group, each of which may have one or more substituents; and R.sub.3 represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group or an aralkyl group, each of which group may have one or more substituents, and a process for their preparation. The imidazothiadiazine derivatives have hypotensive and vasodilating activities and can therefore be used as medicaments.
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patent: 3217001 (1965-11-01), Santilli et al.
patent: 3493573 (1970-02-01), Joullie et al.
Ohsaki et al, Chemical Abstracts, vol. 110, entry 8173u.
Edenhofer et al., Chemical Abstracts, vol. 87:23224m (1977).
G. Garcia-Munoz et al., J. Heterocyclic Chem. vol. 13, No. 4 (1976), pp. 793-796.
J. Barluenga et al., J. Chem. Soc. Perkin Trans. I (1983), pp. 2273-2276.
Kuriki Takeo
Ohsaki Tsutomu
Sakakibara Jinsaku
Ford John M.
Hoechst Japan Limited
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