Imidazoquinoline antithrombrogenic cardiotonic agents

Details Imidazoquinoline antithrombrogenic cardiotonic agents Imidazoquinoline antithrombrogenic cardiotonic agents

1986-02-26

1987-05-26

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 82, A61K 31395, C07D47104

Patent

active

046686860

ABSTRACT:
Novel series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones of the Formula ##STR1## wherein R.sub.1 is halogen, lower alkyl, lower alkoxy, trifluoromethyl; R.sub.2 is hydrogen, halogen, lower alkyl, lower alkoxy; R.sub.3 is hydrogen, halogen, lower alkyl, lower alkoxy; and R.sub.4 is hydrogen or lower alkyl. The compounds are therapeutically useful as inhibitors of blood platelet aggregation and/or as cardiotonic agents.

REFERENCES:
Chem. Abstracts, vol. 102, 1985, 132000j.
Reid, et al., Chem. Ber., 1956, 89, 2684-2687.
J. S. Fleming, et al., New Drugs Annual: Cardiovascular Drugs, Raven Press, pp. 277-294, New York (1983).
Slouka, et al., Synthesis of 1,2,4-Triazino[5,6-b] and Imidazo [4,5-b]quinoline Derivatives, pp. 2628-2634, Coll. Czech. Chem. Commun. 49 (1984).

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