Imidazoquinazoline derivatives which inhibit the aggregation of

Details Imidazoquinazoline derivatives which inhibit the aggregation of Imidazoquinazoline derivatives which inhibit the aggregation of

1982-07-28

1984-06-19

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544250, A61K 31505, C07D48704

Patent

active

044553110

ABSTRACT:
Imidazoquinazolines of the formula ##STR1## wherein one of R.sup.1 or R.sup.2 is hydrogen, chlorine, bromine, C.sub.1-4 -n-alkyl or C.sub.1-4 -n-alkoxy and the other is --N(R,R"), wherein R and R" are C.sub.1-4 -n-alkyl or R and R" taken together are tetramethylene or pentamethylene, and R.sup.3 and R.sup.4, independently, are hydrogen or methyl,
their tautomers, when R.sup.3 and/or R.sup.4 are other than hydrogen, enantiomers thereof, as well as physiologically compatible acid addition salts of such compounds are described. The foregoing compounds inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system. Such compounds are prepared starting from the corresponding 4-benzylimidazo[1,2-a]quinazolin-2(1H)-ones in which the benzyl group is optionally substituted in the ortho- or para-position by C.sub.1-4 -alkyl or C.sub.1-4 -alkoxy.

REFERENCES:
patent: 4256748 (1981-03-01), Chodnekar et al.
patent: 4390540 (1983-06-01), Chodnekar et al.

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