Imidazoquinazoline compounds and their use

Details Imidazoquinazoline compounds and their use Imidazoquinazoline compounds and their use

1992-12-15

1994-12-06

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142332, 514267, 544 60, 544115, 544230, 544250, A61K 31535, A61K 3154, C07D48704

Patent

active

053710800

ABSTRACT:
Imidazoquinazoline compounds having the formula ##STR1## wherein Q is ##STR2## --COOR.sup.8 or --CN; wherein R.sup.1 is H, alkyl, unsubstituted or substituted cycloalkyl, alkoxy, alkoxyalkyl or CF.sub.3 ; R.sup.8 is alkyl; R.sup.2 and R.sup.3 independently are H, alkyl optionally substituted, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonylalkyl, formylalkyl, or an acetal thereof, or R.sup.2 and R.sup.3 together with the N-atom form a 4-6 membered monocyclic amino group in which ring system one or more of the carbon atoms may be exchanged with N, O or S, sulphinyl, sulphonyl or carbonyl or an acetal thereof, each of these ring systems optionally being substituted; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently are H, OH, halogen, CF.sub.3, NO.sub.2, NH.sub.2, CN, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl or alkoxycarbonyl.
The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, in improving the cognitive function of the brain of mammals, or as benzodiazepine antagonists.

REFERENCES:
patent: 4031079 (1977-06-01), Mohrbacher et al.
patent: 4359420 (1982-11-01), Gerecke et al.
patent: 4771051 (1988-09-01), Watjen et al.
patent: 4774245 (1988-09-01), Watjen et al.
patent: 4873244 (1989-10-01), Watjen et al.
Hansen, Chemical Abstracts, vol. 116, No. 174168 (1992) (Abstract for WO 9200298, Jan. 9, 1992).

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