Imidazopyridinium compound and processes for isolating, identify

Details Imidazopyridinium compound and processes for isolating, identify Imidazopyridinium compound and processes for isolating, identify

1989-12-20

1993-05-25

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2713, 530356, 530840, A61K 3170, A61K 3144, C07H 1702, C07H 1904

Patent

active

052141381

ABSTRACT:
The present invention is directed to a novel imidazo [4,5b] pyridinium molecule composed of a lysine and an arginine residue crosslinked with a pentose sugar. The novel imidazo [4,5b] pyridinium compound, referred to as "pentosidine", was isolated from proteineous tissue undergoing advanced glycosylation and is believed to be one of the principal products involved in the non-enzymatic browning and/or aging of proteins. Assaying for the pentosidine molecule makes it possible to assess the degree of aging of proteins in vivo as mediated by pentose induced crosslinking and modulated by disease such as diabetes and nephropathy In addition, the pentosidine molecule may be utilized through the production of monoclonal antibodies thereto and/or the preparation of test kits, etc. for diagnostic, as well as therapeutic purposes (i.e. development of agents which inhibit the non-enzymatic browning reaction, etc.).

REFERENCES:
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patent: 4672031 (1987-06-01), Prockop
patent: 4780452 (1988-10-01), Krenitsky et al.
patent: 4782142 (1988-11-01), Bardos et al.
patent: 4894441 (1990-01-01), Menicagli

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