Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-08-07
1991-04-23
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546118, C07D47104, A61K 3144
Patent
active
050100866
ABSTRACT:
1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4-or 3-pyridinyl, or N-oxides thereof, or phenyl or substituted phenyl.
REFERENCES:
patent: 4276293 (1981-06-01), Lesher et al.
patent: 4294837 (1981-10-01), Lesher et al.
patent: 4374141 (1983-02-01), Lesher et al.
patent: 4963561 (1990-10-01), Lesher et al.
Bacon Edward R.
Kuo Gee-Hong
Lesher, deceased George Y.
Singh Baldev
DuPont Paul E.
Hansen Philip E.
Miltenberger Lenora
Ramsuer Robert W.
Sterling Drug Inc.
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