Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-11-06
1995-07-18
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546121, C07D45302, A61K 3144
Patent
active
054341612
ABSTRACT:
The imidazopyridines compounds of the present invention are serotonergic 5-HT.sub.3 antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, gastric stasis, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
REFERENCES:
patent: 4273778 (1981-06-01), Hadley et al.
patent: 4336259 (1982-06-01), Hadley et al.
patent: 4797387 (1989-01-01), King
patent: 4797406 (1989-01-01), Richardson et al.
patent: 4816453 (1989-03-01), Watts
Fludzinski et al. Inazoles as Indole Bioesters J. Med. Chem. 30 No. 9 1535-7 Apr. 1987.
CA 112(19):178986 (Abstract of the Japanese Paten "L" above) 1988.
Becker Daniel P.
Flynn Daniel L.
Moormann Alan E.
Nosal Roger
Villamil Clara I.
G. D. Searle & Co.
Kovacevic Cynthia S.
Richter Johann
Scalzo Catherine S.
Williams Roger A.
LandOfFree
Imidazopyridines as serotonergic 5-HT.sub.3 antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidazopyridines as serotonergic 5-HT.sub.3 antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazopyridines as serotonergic 5-HT.sub.3 antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2419101